Transcriptional regulation of nf-e2 p45-related factor (NRF2) expression by the aryl hydrocarbon receptor-xenobiotic response element signaling pathway: DIRECT CROSS-TALK BETWEEN PHASE I AND II DRUG-METABOLIZING ENZYMES

The major methyltransferases are: COMT (catechol-O-methyltransferase) : inactivates catecholamines (dopamine, norepinephrine, epinephrine), catechol estrogens, and catechol drugs (L-DOPA) R HNMT (histamine N-methyltransferase) : the primary intracellular histamine degradation enzyme in the brain and peripheral tissues R INMT (indolethylamine N-methyltransferase) : methylates tryptamine, serotonin, and other indoleamines R NNMT (nicotinamide N-methyltransferase) : methylates nicotinamide (vitamin B3) and other pyridines R TMT (thiol S-methyltransferase) : S-methylates thiol drugs (captopril, D-penicillamine) and thiol metabolites R TPMT (thiopurine S-methyltransferase) : methylates thiopurine drugs (azathioprine, 6-mercaptopurine) used in autoimmune disease and cancer R Methylation capacity depends on the methylation cycle: methionine to SAM-e to SAH to homocysteine, recycled back to methionine by methionine synthase (B12-dependent) or BHMT (betaine-dependent)

Targeting the Nrf2 pathway may therefore represent a viable therapeutic strategy to mitigate mycotoxin-induced oxidative stress and prevent the progression to liver fibrosis or cirrhosis
[DOI] [PubMed] [Google Scholar] 25.Martin C.A., Gully D., Naline E., Advenier C
Perform a patch test before use to check for irritation
N bao gm nhiu loi khc nhau, trong 3 loi ph bin v quan trng nht l Alpha Lipoic Acid (ALA), Eicosapentaenoic (EPA) v Docosahexaenoic (DHA)